Topic · Oncology · Medicine

Pancreatic and Hepatic Oncology Research

OpenAlex topic; a paper is listed when OpenAlex scores it at least 0.5 for this topic.

2 papers

Invasion status stratifies the composition of the human pancreatic cancer perineural niche

Zainab Hussain, Dig Vijay Kumar Yarlagadda, Qianzi Li, Nuray Tezcan, Pavel Stupakov, Golabahar Sadatrezaei, Richard J. Wong, Joan Massagué, Zeynep Cagla Tarcan, Olca Baştürk, Sylvie Deborde, Christina S. Leslie, Mara H. Sherman

Xenium and single-nucleus profiling of 14 human pancreatic tumors shows invaded nerve neighborhoods enriched for classical cancer cells, myCAFs and lipid-handling macrophages but depleted of lymphocytes.

bioRxiv · Aug 6, 2026 · PreprintCancer Biology✦ In-depth digest

Oncogenic and tumor-suppressive forces converge on a progenitor niche at the benign-to-malignant transition

Jose Reyes, Isabella S. Del Priore, Andrea C. Chaikovsky, Nikhita Pasnuri, Ahmed M. Elhossiny, Jin Park, Philipp Weiler, Tobias Krause, Andrew R Moorman, Catherine Snopkowski, Meril T. Takizawa, Cassandra Burdziak, Nalin Ratnayeke, Ignas Masilionis, Yu-Jui Ho, , Scott W. Lowe

In mouse pancreatic cancer models, p53, CDKN2A and SMAD4 programs converge on a rare Kras-mutant progenitor-like state whose niche KRAS inhibition collapses and p53 loss expands.

Cell · Apr 15, 2026Peer-reviewedCancer Biology✦ In-depth digest