TRPV4 overactivation enhances cellular contractility and drives ocular hypertension in TGFβ2 overexpressing eyes
Christopher N. Rudzitis, Mónika Lakk, Ayushi Singh, Sarah N. Redmon, Denisa Kirdajová, Yun‐Ting Tseng, Michael Lucio De Ieso, William Daniel Stamer, Samuel Herberg, David Križaj
TGFβ2 raises TRPV4 expression and activity in human trabecular meshwork cells; TRPV4 blockade or deletion lowers TGFβ2-driven ocular hypertension and contractility in mice and hydrogels.
bioRxiv · Nov 5, 2024Physiology✦ In-depth digest