Denisa Kirdajová

Canonical Wnt signaling controls the fate and plasticity of NG2 glia in the healthy and ischemic adult mouse cortex

This study shows Wnt signaling regulates NG2 glia fate in adult mouse cortex, promoting neuronal conversion while impairing oligodendrocyte maturation after ischemic injury.

PU.1-driven enrichment enables microglia profiling from frozen brain tissue using the high-throughput Smart-seq3xpress method

The paper introduces a method to profile microglia from frozen brain tissue using PU.1 as a marker and Smart-seq3xpress, showing improved transcriptomic data compared to standard protocols.

TRPV4 overactivation enhances cellular contractility and drives ocular hypertension in TGFβ2 overexpressing eyes

TGFβ2 raises TRPV4 expression and activity in human trabecular meshwork cells; TRPV4 blockade or deletion lowers TGFβ2-driven ocular hypertension and contractility in mice and hydrogels.

Spatiotemporal transcriptomic map of ischemic brain injury

This study maps the spatiotemporal transcriptomic changes in mouse brain tissue after ischemic injury, revealing glial cell responses and their role in neuroinflammation.

Astrocyte-like subpopulation of NG2 glia in the adult mouse cortex exhibits characteristics of neural progenitor cells and is capable of forming neuron-like cells after ischemic injury

The paper identifies an astrocyte-like NG2 glia subpopulation in adult mouse cortex that shows neurogenic potential and can form neuron-like cells after ischemic injury.

Decoding the transcriptional response to ischemic stroke in young and aged mouse brain

The paper analyzes RNA-Seq data from young and aged mice after ischemic stroke to identify age-related transcriptional changes and inflammatory responses.