Author

Christopher N. Rudzitis

University of UtahORCID 0000-0002-7271-5609Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Research Focus:development & morphogenesis· 2 Assay:electrophysiology· 2 Organism:human· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

David KrižajiD· 4 shared Mónika LakkiD· 4 shared Oleg V. YarishkiniD· 2 shared Sarah N. RedmoniD· 2 shared Yun‐Ting TsengiD· 2 shared Ayushi SinghiD· 1 shared Christina M. NicouiD· 1 shared Christopher L. PassagliaiD· 1 shared

Activity by Year

2024-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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4 shared papersPhysiology

David KrižajORCID

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Author profile →

4 papers

Recent·Most cited

Corticosteroids elevate intraocular pressure through suppression of TREK-1 signaling

Sarah N. Redmon, Oleg V. Yarishkin, Christopher N. Rudzitis, Mónika Lakk, Jacques Bertrand, Joseph M. Sherwood, Christina M. Nicou, Christopher L. Passaglia, Darryl R. Overby, David Križaj

This study shows corticosteroids increase intraocular pressure by suppressing TREK-1 channels in trabecular meshwork cells, leading to ocular hypertension, which can be counteracted by TREK-1 agonists.

bioRxiv · Aug 14, 2025 · PreprintPhysiology

OPN5 and TRPV4 subserve intrinsic photosensitivity in mouse corneal epithelium

Luka Lapajne, Mónika Lakk, Christopher N. Rudzitis, Shruti Vemaraju, Richard A. Lang, Marko Hawlina, David Križaj

The paper investigates UVB-induced calcium signaling in mouse corneal epithelial cells, identifying OPN5 and TRPV4 as key components of an intrinsic photosensitive pathway that triggers cytokine release and inflammatory responses.

The Ocular Surface · Nov 15, 2024Peer-reviewedPhysiology

TRPV4 overactivation enhances cellular contractility and drives ocular hypertension in TGFβ2 overexpressing eyes

Christopher N. Rudzitis, Mónika Lakk, Ayushi Singh, Sarah N. Redmon, Denisa Kirdajová, Yun‐Ting Tseng, Michael Lucio De Ieso, William Daniel Stamer, Samuel Herberg, David Križaj

TGFβ2 raises TRPV4 expression and activity in human trabecular meshwork cells; TRPV4 blockade or deletion lowers TGFβ2-driven ocular hypertension and contractility in mice and hydrogels.

bioRxiv · Nov 5, 2024Physiology✦ In-depth digest

Osmosensing in trabecular meshwork cells

Jackson M. Baumann, Oleg V. Yarishkin, Mónika Lakk, Christopher N. Rudzitis, Yun‐Ting Tseng, David Križaj

This study investigates osmosensing mechanisms in trabecular meshwork cells, identifying TRPV4 and Cl- channels as key players in volume regulation and calcium homeostasis under osmotic stress.

bioRxiv · Apr 3, 2024 · PreprintPhysiology