William Daniel Stamer

The paper identifies 588 differentially expressed genes in glaucomatous versus normal trabecular meshwork cells cultured in a soft ECM environment, revealing three disease-related programs.

The paper uses single-cell RNA sequencing to identify age-related immune remodeling in ocular outflow tissues that may help maintain intraocular pressure.

The paper compares transcriptomic differences between high and low flow regions in mouse and human trabecular meshwork to understand intraocular pressure regulation.

This study examines how dexamethasone-induced ocular hypertension affects segmental outflow and trabecular meshwork stiffness in mice, finding no significant stiffness differences but increased fibronectin in low-flow regions.

The paper identifies 44 SNPs associated with steroid-induced ocular hypertension using a pharmacogenomic approach.

This study shows that microtubule stability affects Schlemm's canal cell mechanics and outflow facility in glaucoma by altering contractility, stiffness, and pore formation.

The paper identifies mitochondrial dysfunction in a glaucoma model using single-cell analysis and shows that vitamin B3 treatment protects against IOP elevation.

This study identifies glucocorticoid-induced transcriptomic changes in human trabecular meshwork and Schlemm's canal cells using RNA-seq, finding genes associated with glaucoma and intraocular pressure.

This study shows that endothelial cell stiffness and type influence biomechanically-induced transcellular pore formation in Schlemms canal cells.

This study identifies KALRN and TMCO1 as interdependent regulators of trabecular meshwork homeostasis and intraocular pressure, linking ER and calcium homeostasis to glaucoma pathogenesis.

This study shows TRPV4 modulates substrate stiffness sensing and transcellular pore formation in Schlemm's canal cells, with implications for glaucoma treatment.

The paper identifies resident tissue macrophages as critical for maintaining intraocular pressure homeostasis by regulating extracellular matrix turnover in the trabecular meshwork.

This study measures anterior and posterior chamber volumes in mice, finding the anterior chamber constitutes 47% of total aqueous humor volume, significantly different from humans, and suggests previous inflow rate estimates may be overestimated.

A magnetic cell therapy reduced intraocular pressure in a glaucoma mouse model, with hAMSCs showing greater efficacy than iPSC-TM cells.

TGFβ2 raises TRPV4 expression and activity in human trabecular meshwork cells; TRPV4 blockade or deletion lowers TGFβ2-driven ocular hypertension and contractility in mice and hydrogels.

The paper performs transcriptomic analyses of Schlemm's canal endothelial cells to reveal their lymphatic identity, three major cell states, and interactions with trabecular meshwork cells.

This study identifies differentially expressed miRNAs and genes in human trabecular meshwork cells under cyclic mechanical stretch, highlighting miRNA-mRNA regulatory interactions in glaucoma-related pathways.

The paper identifies differentially expressed coding and long noncoding RNAs in keratoconus-affected corneas and finds enriched pathways and correlations suggesting their functional roles.