Author

Michael Lucio De Ieso

Duke UniversityORCID 0000-0002-2402-4483Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:drug response / drug discovery· 1 Assay:electrophysiology· 1 Organism:human· 1 Assay:imaging· 1

Frequent Co-Authors

William Daniel StameriD· 2 shared Aleksander O. GrimsrudiD· 1 shared Ayushi SinghiD· 1 shared Christopher N. RudzitisiD· 1 shared Daniel R. SabaniD· 1 shared Darren M. Schuman· 1 shared David KrižajiD· 1 shared Denisa KirdajováiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersImmunology

William Daniel StamerORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Resident Tissue Macrophages Govern Intraocular Pressure Homeostasis

Katy C. Liu, Aleksander O. Grimsrud, María Fernanda Suárez, Darren M. Schuman, Michael Lucio De Ieso, Megan N. Kuhn, Ruth A. Kelly, Rose Mathew, Joan Kalnitsky, Matthias Mack, Florent Ginhoux, Violet Bupp-Chickering, Revathi Balasubramanian, Simon W. M. John, William Daniel Stamer, Daniel R. Saban

The paper identifies resident tissue macrophages as critical for maintaining intraocular pressure homeostasis by regulating extracellular matrix turnover in the trabecular meshwork.

bioRxiv · Jan 25, 2025 · PreprintImmunology

TRPV4 overactivation enhances cellular contractility and drives ocular hypertension in TGFβ2 overexpressing eyes

Christopher N. Rudzitis, Mónika Lakk, Ayushi Singh, Sarah N. Redmon, Denisa Kirdajová, Yun‐Ting Tseng, Michael Lucio De Ieso, William Daniel Stamer, Samuel Herberg, David Križaj

TGFβ2 raises TRPV4 expression and activity in human trabecular meshwork cells; TRPV4 blockade or deletion lowers TGFβ2-driven ocular hypertension and contractility in mice and hydrogels.

bioRxiv · Nov 5, 2024Physiology✦ In-depth digest