Mónika Lakk

This study investigates how stiffness and stretch affect trabecular meshwork cells using a microfluidic system, finding that glaucomatous cells show distinct mechanotransduction issues under combined mechanical stress.

This study shows corticosteroids increase intraocular pressure by suppressing TREK-1 channels in trabecular meshwork cells, leading to ocular hypertension, which can be counteracted by TREK-1 agonists.

TGFβ2 raises TRPV4 expression and activity in human trabecular meshwork cells; TRPV4 blockade or deletion lowers TGFβ2-driven ocular hypertension and contractility in mice and hydrogels.

The paper investigates UVB-induced calcium signaling in mouse corneal epithelial cells, identifying OPN5 and TRPV4 as key components of an intrinsic photosensitive pathway that triggers cytokine release and inflammatory responses.

This study investigates osmosensing mechanisms in trabecular meshwork cells, identifying TRPV4 and Cl- channels as key players in volume regulation and calcium homeostasis under osmotic stress.