Synthesis and biological activity

Synthesis and biological evaluation of glutathione-responsive 2-alkoxycarbonyl allyl niclosamide prodrugs as anticancer agents

This study synthesizes and evaluates glutathione-responsive niclosamide prodrugs as anticancer agents, showing reduced toxicity and tumor growth inhibition in mice.

Macrocyclization of Broad-Spectrum Kinase Inhibitor Bosutinib leads to Potent and Selective Quinoline-based HIPK4 Inhibitor AZ137

The paper describes the development of AZ137, a potent and selective HIPK4 inhibitor derived from bosutinib, and validates its utility as a tool for studying HIPK4's biological functions.

Synthetic derivatives of vinpocetine as antiproliferative agents

This study evaluates two vinpocetine analogs with E-ring modifications, showing dose-dependent antiproliferative activity without significant apoptosis or necrosis.

Exploring the therapeutic potential of a novel series of imidazothiadiazoles targeting focal adhesion kinase (FAK) for pancreatic cancer treatment: Synthesis, mechanistic Insights and promising antitumor and safety profile

This study identifies compound 10l as a potent FAK inhibitor with antitumor activity and safety in pancreatic cancer models.