Topic · Organic Chemistry · Chemistry

Synthesis and biological activity

OpenAlex topic; a paper is listed when OpenAlex scores it at least 0.5 for this topic.

2 papers

Discovery of Niclosamide Analogs with Potent Mitochondrial Uncoupling Activity with reduced toxicity

Haowen Jiang, Alessio Macorano, Enming Xing, Mohamed Jedoui, Shabber Mohammed, Vanessa Lee, Jeffrey K. J. Cheng, Lain McDonough, Xiaolin Cheng, Jiangbin Ye, Pui‐Kai Li

This study develops Niclosamide analogs with improved mitochondrial uncoupling activity and reduced toxicity for cancer treatment.

bioRxiv · Jul 4, 2025 · PreprintPharmacology & Toxicology

Design, Synthesis, Molecular Docking and Biological Activity of Pyrazolopyridines as Promising Lead Candidates Against Mycobacterium tuberculosis

Hulluru Surya Prakash Rao, Ramalingam Gunasundari, Lakshmi Narayana Adigopula, Jayaraman Muthukumaran

The paper synthesizes and evaluates pyrazolopyridine derivatives as potential antitubercular agents, showing promising activity against M. tuberculosis.

bioRxiv · Jun 26, 2023 · PreprintBioinformatics