Jiangbin Ye

This paper identifies Raf1 within mitochondria where it interacts with GLS to regulate glutamine catabolism and tumorigenesis, independent of MAPK signaling.

The paper identifies metabolic differences between ASCL1-high and low SCLC cells, showing that ASCL1-high cells resist ferroptosis via BH4/BH2 antioxidants and are vulnerable to combined cysteine depletion and BH4/BH2 inhibition.

This study develops Niclosamide analogs with improved mitochondrial uncoupling activity and reduced toxicity for cancer treatment.

This study identifies uridine metabolism as a therapeutic target for chemo-resistant B-ALL by linking active signaling to uridine dependency and demonstrating DHODH inhibition as a promising treatment.

This study shows glucose acts as a morphogen that modulates transcription factor dimerization during tissue differentiation.