Circadian rhythm and melatonin

Epigenetic characterization and manipulation of rare circadian neuron subtypes

El-INTACT nuclear purification gives clean ATAC-seq from ~120 Drosophila clock neurons and 16 PDF neurons, revealing cell-type-specific Clk enhancers; disrupting two renders flies arrhythmic.

Circadian transcriptome in cultured cells depends on synchronisation method and differs from in vivo condition

Heat shock, dexamethasone and osmotic stress all entrain the clock of primary mouse chondrocytes but yield distinct rhythmic transcriptomes, overlapping only marginally with each other and in vivo cartilage.