Circadian rhythm and melatonin

From womb to crib: How fetal activity patterns in utero reveal postnatal sleep behavior

This study examines how fetal activity patterns in utero relate to postnatal infant sleep behavior, finding that fetal circadian entrainment predicts infant sleep preferences.

The CK2 and DBT kinases promote temperature compensation of the Drosophila circadian clock via distinct pathways

This study identifies DBT and CK2 kinases as critical for temperature compensation in Drosophila circadian clocks through distinct phosphorylation pathways.

Epithelial function of the circadian clock gene, Bmal1, in regulating the mucosa.

This study shows that Bmal1 in colon epithelial cells promotes mucus production and is essential for sex-specific tissue regeneration after injury.

Molecular Shape Evolution of Cyanobacterial Circadian Clock Protein KaiC

This paper traces the molecular shape evolution of KaiC, a circadian clock protein, showing it evolved from an asymmetric hexamer to a compact symmetric hexamer and a dodecamer over 3.1 billion years.

Circadian photoreceptor CRYPTOCHROME promotes wakefulness under short winter-like days via a GABAergic circuitry

The paper shows that cryptochrome (CRY) in fruit flies reduces GABAergic inhibition under short days, increasing wakefulness and mirroring SAD hypersomnolence.

Attractive and repulsive couplings between circadian pacemaker neurons promote entrainment to light-dark cycles with after-effect

The paper models circadian pacemaker neuron interactions to show how attractive and repulsive couplings between SCN core and shell regions enable entrainment to light-dark cycles and produce the after-effect.

Light stimulation system for measuring pupillary light responses based on Maxwellian view optical system using a retina presentation type viewfinder

This paper introduces a Maxwellian view-based viewfinder for measuring pupillary light responses and compares its effectiveness to an LED system, finding it enhances PIPR amplitude and sustained slope.

Conserved circadian membrane rhythms arise from divergent cellular mechanisms in pacemaker neurons of mice and Drosophila

The paper compares circadian membrane rhythms in mouse and Drosophila pacemaker neurons, finding conserved functional goals but divergent electrophysiological mechanisms across species.

Integrated Respirometry and Metabolomics Unveil Circadian Metabolic Dynamics in Drosophila

This study combines respirometry and metabolomics to analyze circadian metabolic dynamics in Drosophila, showing how sleep and circadian disruptions affect metabolic rates and redox homeostasis.

Phase response curve and RNA-sequencing demonstrate spiders' sensitivity to light and pinpoint candidate light-responsive genes

The paper uses phase response curves and RNA-sequencing to show spiders' sensitivity to light and identify candidate light-responsive genes.

Mating imperatives drive plasticity of the daily temporal niche in fruit flies.

The paper shows that sociosexual interactions in fruit flies can shift their daily activity patterns, enabling coexistence by altering temporal niches.

Macrophages promote collagen deposition through circadian regulation of fibroblasts

This study shows macrophages enhance collagen deposition in fibroblasts through circadian regulation, with M2 macrophages using PDGFA to strengthen circadian rhythms and increase collagen production.

Genetic and Environmental Predictors of Seasonality and Seasonal Affective Disorder in Individuals with Depression

This study identifies genetic and environmental factors associated with seasonal affective disorder and seasonality using a large cohort of individuals with depression.

Region-specific Bmal1 deletion in the dorsal striatum alters alcohol consumption in a sex-specific manner

This study shows that deleting Bmal1 in the dorsal striatum's DMS region reduces alcohol consumption in female mice but not males, with effects dependent on ovarian hormones.

Cell-Autonomous and Systemic Circadian Regulation of Gene Expression in Adipocytes

The paper identifies cell-autonomous and systemic circadian gene expression programs in adipocytes using RNA sequencing and motif analysis, revealing distinct regulatory programs linked to metabolic processes.

Cell-type-specific circadian and light-responsive transcriptional dynamics in adult Drosophila neurons

The paper profiles circadian neuron transcriptomes across timepoints under different light conditions to reveal transcriptional and light-dependent gene regulation in Drosophila.

Drosophila Pyruvate Kinase Links Metabolic State with Circadian Output via TARANIS and PDF

This study shows that Pyruvate Kinase (Pyk) regulates circadian rhythms in Drosophila by affecting PDF protein levels through the TARANIS co-regulator.

Daylight, Daily Rhythms, and Downstream Physiology: A Translational Study in Diurnal Nile Grass Rats (Arvicanthis niloticus)

This study examines how different lighting conditions affect circadian rhythms and physiology in diurnal Nile grass rats, finding that daylight-equivalent lighting produces stronger circadian entrainment and better physiological outcomes than fluorescent lighting.

Core circadian clock genes control molecular and behavioral circatidal rhythms in Parhyale hawaiensis

The paper shows that core circadian clock genes control both circadian and circatidal rhythms in Parhyale hawaiensis, with distinct transcriptional wiring in circatidal neurons.

Convergent latitudinal erosion of circadian systems in a rapidly diversifying order of fishes

This study investigates circadian gene loss in perciform fishes across latitudes, finding greater loss in higher-latitude species and no circadian metabolic oscillations in some notothenioid species.

Social Context Suppresses Food Anticipatory Activity and Associated Thermoregulation in Mice

This study shows that social housing suppresses food anticipatory activity and thermoregulation in mice, indicating social context influences circadian rhythms.

Circadian temperature compensation is intrinsically linked with metabolism and redox signaling

This study identifies a link between circadian temperature compensation and metabolic redox signaling, showing that metabolic sensing modulates the core circadian mechanism to maintain period stability across temperatures.

11β-HSD2 buffers fetal glucocorticoid exposure inducing Per1 expression under maternal stress

This study shows that 11β-HSD2 buffers maternal glucocorticoid surges during early development, preventing premature circadian clock activation and segmentation defects.

The astrocyte clock controls circadian perineuronal net remodeling, synapse strength and learning behavior

This study shows that astrocyte-specific deletion of Bmal1 disrupts circadian rhythms in perineuronal nets, synaptic plasticity, and learning behavior.

Chrono-atlas of cell-type specific daily gene expression rhythms in the regenerating colon

The paper analyzes daily gene expression rhythms in the regenerating colon using single-cell transcriptomics, revealing cell-type specific patterns and identifying a resource for future studies.

Defining and detecting global transcriptional amplitude in circadian gene expression

The paper analyzes circadian gene expression amplitude across multiple human tissues and finds that global transcriptional amplitude varies by individual and tissue, but is not strongly correlated with core clock gene metrics.

Diurnal regulation of Acyl-CoA synthetase 3 (ACSF3) underlies daily mitochondrial lysine-malonylation and hepatic metabolism

This study identifies ACSF3 as a diurnal regulator of lysine-malonylation and hepatic metabolism, showing its rhythmic expression and role in glycogen storage, lipogenesis, and triglyceride synthesis.

Photoreceptor-specific scene statistics reveal melanopic structure in natural environments

The paper quantifies melanopic input from natural scenes across different environments and photoreceptors, finding structured spatial variation and power-law patterns in melanopic luminance.

Circadian immunometabolic states impart a temporal response to SARS-CoV-2 spike proteins in mammalian macrophages

This study investigates how circadian rhythms affect macrophage responses to SARS-CoV-2 spike proteins, finding that timing of exposure leads to distinct immunometabolic states.

Live-cell imaging enables reporter-free monitoring of the circadian rhythm in individual Synechocystis cells

The paper uses live-cell imaging to monitor circadian rhythms in Synechocystis cells without reporters, finding no circadian gating of cell division but rhythmic changes in refractive index.