Judith Alison Hoyland

This study shows that heat pulses can restore circadian rhythms in cartilage by modulating heat shock proteins and circadian clock genes.

Heat shock, dexamethasone and osmotic stress all entrain the clock of primary mouse chondrocytes but yield distinct rhythmic transcriptomes, overlapping only marginally with each other and in vivo cartilage.

This paper introduces TomoSAXS to map fibril-to-fibre mechanics in intervertebral discs and shows how pre-strain and strain variability correlate with mechanical behavior.

The paper uses peptide location fingerprinting to identify age- and disease-related structural changes in proteins across species and tissues.