Shlesha Richhariya

El-INTACT nuclear purification gives clean ATAC-seq from ~120 Drosophila clock neurons and 16 PDF neurons, revealing cell-type-specific Clk enhancers; disrupting two renders flies arrhythmic.

The paper shows that disrupting mitochondrial fusion in Drosophila neurons leads to a Warburg-like metabolic response that protects against neurodegeneration.

This study shows that female Drosophila circadian rhythms are less affected by mutations in the PDF pathway compared to males, suggesting greater resilience in female circadian timekeeping.

This study identifies Orai-mediated Ca2+ entry as a key regulator of gene expression in flight-promoting dopaminergic neurons, essential for their functional maturation and flight behavior.

The paper uses CRISPR-based methods to disrupt circadian genes in specific Drosophila neurons, revealing distinct functions of cryptochrome and PDF in circadian behavior.

The paper identifies dopamine and GPCR-mediated modulation in Drosophila clock neurons that regulate sleep timing.

The paper shows that IP3/Ca2+ signals in specific neurons drive dSET2 expression, which regulates gene expression through H3K36 methylation to enable pupariation under protein deficiency.