Cardiac Imaging and Diagnostics

Evaluation of Iodine-Based Contrast Agents for Ex Vivo Micro-CT Imaging of Porcine Hearts: An Application to Cardiac Conduction System Imaging

This study compares two iodine-based contrast agents for micro-CT imaging of porcine hearts, finding that I2E provides better contrast and preservation while I2KI offers faster staining but more artifacts.

Linking coronary microvascular structure and function in preclinical models of coronary microvascular disease

This study quantifies coronary microvascular structure and function in mouse models of CMVD, identifying age, sex, and metabolic factors as key contributors to disease.

Micro-CT: A reversible contrast-based protocol for non-destructive imaging of cardiac morphology in an avian model.

This study develops a micro-CT protocol for 3D cardiac morphology imaging in avian embryos, followed by antigen preservation for downstream analysis.

Dynamic Fluoroleucine PET Detects Impaired Cardiac Leucine Uptake Before Hypertensive Left Ventricular Hypertrophy Develops

This paper uses [18F]FLE-PET/CT to detect reduced cardiac leucine uptake in hypertensive rats before LVH develops, suggesting it as an early marker for cardiometabolic dysfunction.

Computational modeling of left ventricular flow using PC-CMR-derived four-dimensional wall motion

This study integrates MRI modalities with computational fluid dynamics to model left ventricular flow, improving clinical assessment of cardiac hemodynamics without complex myocardial modeling.

Sarcolemmal and mitochondrial membrane potentials measured ex vivo and in vivo in the heart by pharmacokinetic modelling of sestamibi

The paper estimates sarcolemmal and mitochondrial membrane potentials in the heart using pharmacokinetic modeling of sestamibi data from ex vivo and in vivo experiments.

Molecular Imaging of Collagen Turnover in Myocardial Infarction

This paper evaluates 99mTc-(HE)-(GPO) as a radiotracer for detecting collagen turnover in myocardial infarction, showing higher uptake in infarct zones and specificity for denatured collagen.

An animal model of coronary microvascular dysfunction (CMD) in the female spontaneously hypertensive rat: the role of diet

This study shows that female spontaneously hypertensive rats develop diet-dependent coronary microvascular dysfunction, which can serve as a model for hypertension-related CMD.

Identifying myocardial regions perfused by coronary arteriesthrough detailed human microvasculature data

The paper uses detailed human coronary microvasculature data to build a tool for personalized coronary-myocardium association and assesses its impact on myocardial perfusion simulations.

Detection of Diffuse to Focal Myocardial Fibrosis by Cardiovascular Magnetic Resonance Against Histology in Mini-Swine

This paper validates cardiovascular magnetic resonance (CMR) methods for detecting myocardial fibrosis in mini-swine against histology, finding that T1-mapping outperforms LGE for low-grade fibrosis.

Towards Principled Modeling Of Coronary Artery Calcium Scores With Zero-Inflated Regression

This paper develops zero-inflated regression models to better analyze Coronary Artery Calcium Scores by addressing the high prevalence of zeros in the data.

Perfusion-Independent Tissue Hypoxia in Cardiac Hypertrophy in Mice Measured by 64Cu-CTS PET Imaging

This study shows that 64Cu-CTS PET detects hypoxia in hypertrophic mouse hearts independent of perfusion, linking it to structural changes and metabolic shifts.

Multiscale cardiac imaging to capture the whole heart and its internal cellular architecture, with applications to congenital heart disease

The paper presents a multiscale imaging technique combining micro-CT and SEM to study whole heart structure and ultrastructure in congenital heart disease models.