This paper evaluates 99mTc-(HE)-(GPO) as a radiotracer for detecting collagen turnover in myocardial infarction, showing higher uptake in infarct zones and specificity for denatured collagen.

bioRxiv · Jan 20, 2026 · PreprintBioengineering

Aging, matrix metalloproteinase imaging, and survival prospects in aortic aneurysm

Mean Ghim, Onur Varli, Azmi A. Ahmad, Afarin Neishabouri, Gunjan Kukreja, ZhengXing Zhang, Saalar Zarnegar, Nicholas T. Gangemi, Jakub Toczek, Jiasheng Zhang, Chi Liu, Yongjian Liu, Robert J. Gropler, Mehran M. Sadeghi

This study investigates how aging affects aortic MMP activity and aneurysm development using MMP-targeted imaging, finding increased MMP activity and worse survival in older mice.

bioRxiv · Jan 2, 2026 · PreprintBioengineering

A correlative quantitative phase contrast and fluorescence super-resolution microscope for imaging molecules in their cellular context

Yujin Bao, Zach Marin, Xiongchao Chen, Qiong Liu, Yazgan Tuna, Sylvi Stoller, Florian Schueder, Chuyue Zhang, Suet Yin Sarah Fung, Min Wu, Karla M. Neugebauer, Jonathon Howard, Chi Liu, David Baddeley, Michael I. Shribak, Joerg Bewersdorf

The paper develops a combined microscope platform that integrates quantitative phase contrast and super-resolution fluorescence imaging for high-sensitivity visualization of sub-cellular structures and molecules in their cellular context.

Biophysical Journal · Feb 1, 2024Peer-reviewedCell Biology