Pharmaceutical Practices and Patient Outcomes

Frailty, polypharmacy, deprescribing and 23-hour activity: insights from a mouse model

This study examines how polypharmacy, monotherapy, and deprescribing affect activity and frailty in aged mice, revealing reversible and irreversible effects on behavior and frailty trajectories.

Interplay between polygenic effects and polypharmacy on dementia: An investigation in an elderly Scottish cohort.

The paper investigates the interaction between polygenic risk scores for Alzheimer's dementia and polypharmacy in predicting future dementia risk in an elderly Scottish cohort.

Computational Drug Recommendation Approaches toward Safe Polypharmacy

The paper develops a joint model to recommend safe or to-avoid drugs in polypharmacy scenarios and creates datasets for evaluating drug-drug interactions.