Author

Sarah Nicole Hilmer

The University of SydneyORCID 0000-0002-5970-1501Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:development & morphogenesis· 2 Research Focus:host-pathogen & immune response· 2 Assay:behavioral assay· 1 Research Focus:cell type annotation· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

John R. MachiD· 2 shared Kevin WinardiiD· 2 shared Brent Vander WykiD· 1 shared Bryony L. WintersiD· 1 shared Carina L. BlakeriD· 1 shared Charlie W Gregson· 1 shared Dina Spigseth Hovland· 1 shared Elizabeth ClarkeiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersPharmacology & Toxicology

John R. MachORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Pharmacology & ToxicologyThe Journals of Gerontology Series APeer-reviewedJun 30, 2026

Frailty, polypharmacy, deprescribing and 23-hour activity: insights from a mouse model

John R. Mach, Kevin Winardi, Sarah Nicole Hilmer

This study examines how polypharmacy, monotherapy, and deprescribing affect activity and frailty in aged mice, revealing reversible and irreversible effects on behavior and frailty trajectories.

DOI 10.1093/gerona/glag170

mousebehavioral assay

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Pharmacology & ToxicologyJournal of Pharmacology and Experimental TherapeuticsPeer-reviewedJun 4, 2026

Sublethal stress from polypharmacy modulates scavenging function and fenestrations in mouse liver sinusoidal endothelial cells

Kajangi Gnanachandran, Dina Spigseth Hovland, Jakub Pospíšil…·Peter McCourt

This study examines how polypharmacy affects liver sinusoidal endothelial cells, showing drug- and concentration-dependent changes in fenestrations and endocytosis.

1 citationtop 4%

mouseexperimental assay

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Pharmacology & ToxicologybioRxivPreprintOct 22, 2025

Effect of prescribing and deprescribing oxycodone on pain and function in a mouse model of osteoarthritis: impact of polypharmacy and sex on response

John Mach, Carina L. Blaker, Bryony L. Winters…·Sarah Nicole Hilmer

This study evaluates the effects of oxycodone prescribing and deprescribing in a mouse model of osteoarthritis, showing that polypharmacy worsens outcomes and sex differences exist in treatment response.

DOI 10.1101/2025.10.22.684045

mouseexperimental assay

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