Tom C. Russ

Gene-by-Sleep Duration Interaction for Glycemic Traits in over 480,000 Individuals

The paper identifies 16 genetic loci interacting with sleep duration to influence glycemic traits in over 480,000 individuals, revealing distinct biological mechanisms for short and long sleep.

Domains of Frailty as Early Risk Factors for Alzheimer's Disease -- Genetic and Causal Evidence

This study identifies distinct frailty domains with varying causal relationships to Alzheimer's disease using genetic methods.

Brain maps of general cognitive function and spatial correlations with neurobiological cortical profiles

The paper identifies brain regions most related to general cognitive function and links them to neurobiological properties using meta-analysis and multimodal cortical maps.

Interplay between polygenic effects and polypharmacy on dementia: An investigation in an elderly Scottish cohort.

The paper investigates the interaction between polygenic risk scores for Alzheimer's dementia and polypharmacy in predicting future dementia risk in an elderly Scottish cohort.

DNAm scores for serum GDF15 and NT-proBNP levels associate with a range of traits affecting the body and brain

The paper develops epigenetic scores for GDF15 and NT-proBNP levels, showing associations with disease risks and brain health traits in two cohorts.

Multi-Polygenic prediction of Frailty and its Trajectories highlights Chronic Pain, Rheumatoid Arthritis, and Educational Attainment pathways

This paper uses multi-polygenic scores to predict frailty and its trajectories, identifying chronic pain, rheumatoid arthritis, and educational attainment as key pathways.

General and specific patterns of cortical gene expression as substrates of complex cognitive functioning

The paper identifies general and specific patterns of cortical gene expression related to cognitive functioning using principal component analysis and validates them across datasets.

Validation of a polygenic risk score for Frailty in the Lothian Birth Cohort and English Longitudinal Study of Ageing

This study validates a polygenic risk score for frailty using two independent cohorts, showing it predicts frailty at early ages with moderate variance explained.

A comparison of blood and brain-derived ageing and inflammation-related DNA methylation signatures and their association with microglial burdens

This study compares DNA methylation signatures of ageing and inflammation in blood and brain tissues, finding divergent correlations and a link between epigenetic age acceleration and microglial burdens in the hippocampus.

Epigenetic predictors of lifestyle traits applied to the blood and brain

The paper applies blood-derived epigenetic predictors of lifestyle traits to brain samples, finding variable correlations across brain regions and a strong link between smoking and the dorsolateral prefrontal cortex.

Variation in VKORC1 is associated with vascular dementia

The paper investigates the association between VKORC1 genetic variation and dementia risk, finding a link with vascular dementia but not general or Alzheimer dementia, and no effect of warfarin use on risk.

Three major dimensions of human brain cortical ageing in relation to cognitive decline across the 8th decade of life.

This study identifies three dimensions of cortical ageing in the human brain and links the most general dimension to cognitive decline across multiple domains in older adults.

A meta-analysis of genome-wide association studies of epigenetic age acceleration

This paper conducts GWAS on two epigenetic age acceleration measures, identifying genetic variants and genes associated with each, and highlighting differences in their genetic architectures.