Author

John R. Mach

The University of SydneyORCID 0000-0002-6896-6376Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:behavioral assay· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Sarah Nicole HilmeriD· 2 shared Dina Spigseth Hovland· 1 shared Jakub PospíšiliD· 1 shared Kajangi GnanachandraniD· 1 shared Karolina SzafranskaiD· 1 shared Kevin WinardiiD· 1 shared Peter McCourtiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

7 top collaborators · 16 mutual co-author links

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2 shared papersPharmacology & Toxicology

Sarah Nicole HilmerORCID

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2 papers

Recent·Most cited

Pharmacology & ToxicologyThe Journals of Gerontology Series APeer-reviewedJun 30, 2026

Frailty, polypharmacy, deprescribing and 23-hour activity: insights from a mouse model

John R. Mach, Kevin Winardi, Sarah Nicole Hilmer

This study examines how polypharmacy, monotherapy, and deprescribing affect activity and frailty in aged mice, revealing reversible and irreversible effects on behavior and frailty trajectories.

DOI 10.1093/gerona/glag170

mousebehavioral assay

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Pharmacology & ToxicologyJournal of Pharmacology and Experimental TherapeuticsPeer-reviewedJun 4, 2026

Sublethal stress from polypharmacy modulates scavenging function and fenestrations in mouse liver sinusoidal endothelial cells

Kajangi Gnanachandran, Dina Spigseth Hovland, Jakub Pospíšil…·Peter McCourt

This study examines how polypharmacy affects liver sinusoidal endothelial cells, showing drug- and concentration-dependent changes in fenestrations and endocytosis.

1 citationtop 4%

mouseexperimental assay

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