Kevin Winardi

This study examines how polypharmacy, monotherapy, and deprescribing affect activity and frailty in aged mice, revealing reversible and irreversible effects on behavior and frailty trajectories.

The paper shows that nuclear actin and replication stress regulate telomerase recruitment to telomeres via ATR and mTOR, enabling telomere length maintenance in human cells.

This study evaluates the effects of oxycodone prescribing and deprescribing in a mouse model of osteoarthritis, showing that polypharmacy worsens outcomes and sex differences exist in treatment response.