Neonatal Respiratory Health Research

This study identifies a human fetal lung progenitor cell population with alveolar fate potential and develops an organoid system to study alveolar development mechanisms.

The paper uses single-cell transcriptomics and in-situ imaging to study lung mesenchymal cell diversity during development and hyperoxia, finding delayed diversity and emergence of Acta1+ cells under hyperoxic conditions.

The paper profiles the transcriptional development and injury sensitivity of lung endothelial subtypes during postnatal growth, revealing distinct transcriptomic changes and differential responses to hyperoxia.

This study identifies rMC-Sca1PosFgf10Pos cells as a functional population critical for maintaining AT2 stem cell self-renewal and differentiation in mice, with implications for fibrosis and COVID-19 pathogenesis.

The paper identifies TGFBI as a protein promoting NF-kappa-B mediated angiogenesis during early lung development by enhancing nitric oxide production.

This study identifies a repair-supportive mesenchymal cell population critical for lung epithelial regeneration through single-cell RNA sequencing and lineage tracing.

The paper uses novel imaging and computational approaches to deduce how distal air exchange surfaces in the lung form through epithelial buckling and extrusion, stabilized by elastin and collagen rings.