Diabetes Management and Research

Patient-specific deep offline artificial pancreas for blood glucose regulation in type 1 diabetes

This paper develops a deep reinforcement learning algorithm for automated insulin dosing in type 1 diabetes, incorporating patient-specific carbohydrate intake and physical exercise.

Ultra-stable insulin-glucagon fusion protein exploits an endogenous hepatic switch to mitigate hypoglycemic risk

This paper develops an ultra-stable insulin-glucagon fusion protein that exploits a hepatic glucose switch to reduce hypoglycemic risk in diabetes, showing improved stability and glycemic control in rats.

New model of glucose-insulin regulation characterizes effects of physical activity and facilitates personalized treatment evaluation in children and adults with type 1 diabetes

The paper develops a glucose-insulin model to simulate the effects of physical activity on blood glucose in type 1 diabetes, enabling personalized treatment evaluation.

Interpreting blood GLUcose data with R package iglu

The paper introduces an R package called iglu for analyzing and visualizing continuous glucose monitoring data, with a user-friendly GUI for accessibility.

CarbMetSim: A Discrete-Event Simulator for Carbohydrate Metabolism in Humans

CarbMetSim simulates blood glucose levels in response to diet and exercise by modeling key organs and metabolic pathways, capturing the average impact of insulin and insulin resistance.

R Functions for Analysis of Continuous Glucose Monitor Data

The paper develops R functions for standardized CGM data analysis, providing comprehensive summary measures comparable to commercial software.

Logical design of oral glucose ingestion pattern minimizing blood glucose in humans

The paper develops a mathematical model to predict an optimal glucose ingestion pattern that minimizes peak blood glucose levels in humans, validated through experimental testing.

Feasibility of automated insulin delivery guided by continuous glucose monitoring in extremely preterm infants

This study evaluates closed-loop insulin delivery guided by continuous glucose monitoring in extremely preterm infants, showing improved glucose control without increased hypoglycaemia.

Urine Glucose Levels Are Disordered Before Blood Glucose Levels Increase In Zucker Diabetic Fatty Rats

This study shows that urine glucose levels become disordered before blood glucose rises in ZDF rats, suggesting urine glucose could be an early diagnostic marker for diabetes.