Diabetes Management and Research

Agreement between Garmin and Ultrahuman wearables and their association with continuous glucose monitoring: an n-of-1 study

This study compares agreement between Garmin and Ultrahuman wearables and their association with continuous glucose monitoring in one adult, finding close agreement on sleep duration but variable heart rate and glucose correlations.

Controlled In Vitro Characterization of the Dynamic Response of Continuous Glucose Monitoring Systems: Adaptation of a Programmable Flow Platform and Decomposition of Dynamic Error

This paper develops a programmable flow platform to assess CGM systems' dynamic response and introduces metrics to decompose dynamic error into its components.

Kinetics of Hypoglycemia in Diabetes Patients Informs Development of New Modes of Glucagon Therapy

The paper analyzes CGM data to understand hypoglycemia kinetics in T1D patients, leading to the development of new glucagon delivery systems for improved therapy.

Title: Zero-shot automated insulin delivery for type 1 diabetes via dynamic physiology-aware reinforcement learning

This paper develops DPARC, a zero-shot insulin delivery system using reinforcement learning to adapt to physiological changes without prior personalization, showing improved glucose control in simulations and pigs.

Decoding Diabetes: Harnessing AI to Accurately Predict Real-Time and Future Blood Glucose Levels for Diabetes Management Using Diet, Exercise, Insulin Intake, and Heart Rate Variability

This paper introduces DTRE, an AI model that predicts real-time and future blood glucose levels using diet, exercise, insulin intake, and heart rate variability, outperforming existing models and commercial CGM systems.

An ultra-long acting insulin enables glucose-synchronised release

This paper develops a glucose-responsive insulin analogue with ultra-long duration and glucose-synchronised release, showing prolonged normoglycaemia in diabetic mice and minipigs.

Robust non-invasive detection of hyperglycemia in mouse models of metabolic dysregulation: the novel Urination Index biomarker

This paper introduces a non-invasive method to detect hyperglycemia in mice using the Urination Index, correlating bedding moisture with blood glucose levels to monitor diabetes progression continuously.

The selfish yet forgetful brain: Stable cerebral oxygen metabolism during hypoglycemia but impaired memory consolidation

Comparative Study between In-silico and Clinical Works on the Control of Blood Glucose Level in People with Type 1 Diabetes using Improved Hovorka Equations

This study compares in-silico simulations using improved Hovorka equations with clinical data to assess their effectiveness in maintaining normoglycemia in type 1 diabetes patients.

CARDIOVASCULAR AUTONOMIC NEUROPATHY IN TYPE 1 DIABETES IS ASSOCIATED WITH SEVERAL METABOLIC PATHWAYS: New Risk Markers on the horizon

The paper identifies metabolic pathways associated with cardiovascular autonomic neuropathy in type 1 diabetes using metabolomics and lipidomics analyses.

Analysis of the transcriptome and DNA methylome in response to acute and recurrent low glucose in human primary astrocytes

This study examines gene expression and DNA methylation changes in human astrocytes exposed to acute and recurrent low glucose, identifying UPR-related gene activation and methylation patterns.

CGMTSA: An R package for continuous glucose monitoring time series data analysis

CGMTSA is an R package for analyzing continuous glucose monitoring time series data, offering tools for missing data imputation, metric calculation, and visualization.

Pan-organ model integration of metabolic and regulatory processes in type 1 diabetes

The paper develops a whole-body model of T1D integrating metabolic and regulatory processes to predict pathophysiological mechanisms and potential therapeutic targets.

Human primary astrocytes increase basal fatty acid oxidation following recurrent low glucose to maintain intracellular nucleotide levels

This study shows that human astrocytes increase fatty acid oxidation under recurrent low glucose to maintain nucleotide levels, indicating mitochondrial dysfunction in hypoglycemia response.