Corneal surgery and disorders

Genome-wide association study of corneal dystrophy uncovers novel risk loci and enables improved polygenic prediction of Fuchs endothelial corneal dystrophy

This paper identifies 24 risk loci for corneal dystrophy, constructs polygenic risk scores (PRS) and STR-based models, and shows PRS improves FECD prediction, while STR expansion is the strongest predictor.

Integration of mechanical testing, in vivo optical coherence elastography and personalized finite element modeling to predict geometrical outcomes of corneal cross-linking

This paper predicts corneal topographic changes after cross-linking using finite element models calibrated with mechanical tests and in vivo optical coherence elastography.

Intrastromal graft of anterior lens capsule. A substitute for Bowman layer graft transplantation for keratoconus.

This study evaluates the use of anterior lens capsule as a graft substitute for Bowman layer in keratoconus treatment, showing preservation of corneal transparency and structure in a rabbit model.

A Mouse Model of Brittle Cornea Syndrome caused by mutation in Zfp469.

This paper creates a mouse model of Brittle Cornea Syndrome to study the molecular mechanisms of corneal thinning and its pathogenic effects.

Aberrant DNA methylation of miRNAs in Fuchs endothelial corneal dystrophy

The paper identifies aberrant DNA methylation of miRNA genes, particularly miR-199B, in Fuchs endothelial corneal dystrophy, linking it to dysregulated extracellular matrix production through miR-199b-5p suppression of Snai1 and ZEB1.

Quantification of double stranded DNA breaks and telomere length as proxies for corneal damage and replicative stress in 64 human keratoconus corneasThe role of DNA damage in the development of keratoconus

This study quantifies DNA damage and telomere length in keratoconus corneas to assess oxidative stress and replicative stress, finding no significant DNA damage differences but longer telomeres in keratoconus.

Differential Expression of Coding and Long Noncoding RNAs in Keratoconus-affected Corneas

The paper identifies differentially expressed coding and long noncoding RNAs in keratoconus-affected corneas and finds enriched pathways and correlations suggesting their functional roles.