Cardiac Arrest and Resuscitation

How long is the brain perfusable after global ischemia? A systematic review

This review assesses the duration of cerebral perfusion after global ischemia, finding a gradual decline rather than a sharp threshold, with variability across studies.

Metformin-mediated mitochondrial protection post-cardiac arrest improves EEG activity and confers neuroprotection and survival benefit

This study shows metformin improves survival, brain function, and mitochondrial health after cardiac arrest in rats.

Overnight caloric restriction prior to cardiac arrest and resuscitation leads to improved survival and neurological outcome in a rodent model

The paper shows that overnight caloric restriction before cardiac arrest and resuscitation improves survival and neurological outcomes in rodents, independent of SIRT-1 and BDNF.

Assessment of Brain Glucose Metabolism Following Cardiac Arrest by FDG Positron Emission Tomography

This study uses [18F]FDG-PET to assess brain glucose metabolism 72 hours after cardiac arrest in mice, finding increased uptake in multiple brain regions.