Aging represses lung tumorigenesis and alters tumor suppression
Emily G. Shuldiner, Saswati Karmakar, Min K. Tsai, Jess D. Hebert, Yuning J. Tang, Laura Andrejka, Maggie R. Robertson, Minwei Wang, Colin R. Detrick, Hongchen Cai, Rui Tang, Christian A. Kunder, David M. Feldser, Dmitri A. Petrov, Monte M. Winslow
This study shows aging suppresses lung tumor initiation and growth in mice, with age-dependent effects on tumor suppressor genes like PTEN and persistent age-related transcriptomic changes in tumors.
Nature Aging · Nov 4, 2025Peer-reviewedCancer Biology