Oswald Steward

This paper develops a miniaturized bioluminescent platform for imaging structured RNAs in live cells, achieving a 3-fold reduction in tag size compared to existing methods.

This study investigates the effects of AAV-mediated CSPG digestion and PTEN knockdown on functional recovery after cervical spinal cord injury, finding that CSPG degradation alone or combined with PTEN suppression impairs motor function.

This paper develops a workflow for spatial transcriptomic analysis of human skeletal muscle biopsies and identifies gene expression signatures related to reinnervation outcomes.

The paper uses multiplexed smFISH to analyze the spatial organization of 15 synaptic neuropil localized mRNAs in rodent hippocampus, finding that colocalization patterns scale with mRNA abundance.

This paper introduces a double transgenic mouse model to track neurodegeneration in 5xFAD mice, revealing age-dependent extracellular hAPP aggregation and tdTomato persistence in degenerating neurons.

This study shows that deleting PTEN in adult dentate gyrus neurons leads to hyperexcitable circuits and spontaneous seizures without neuron death.

The paper identifies a class of spontaneously regenerative corticospinal neurons in mice that project ipsilaterally and share molecular features with embryonic-like regenerating neurons.

This study uses AAV-rg/Cre to delete PTEN in spinal pathway cells after SCI, improving forelimb motor recovery but causing late-onset pathophysiologies in mice.

This paper introduces a bioluminescent platform for tracking RNA in vivo, demonstrating single-copy detection and robust imaging in cells and live animals.

The paper shows that overnight caloric restriction before cardiac arrest and resuscitation improves survival and neurological outcomes in rodents, independent of SIRT-1 and BDNF.

The paper investigates rostro-caudal specificity of corticospinal tract projections in mice using retrograde labeling and injection techniques, revealing distinct termination patterns in different spinal cord regions.

The paper identifies Arc as an activity-dependent gene involved in neurogenic inflammation through intercellular signaling via extracellular vesicles.

The paper characterizes spreading depolarization and repolarization during cardiac arrest in a rodent model and links their timing to neurological recovery outcomes.