Guilian Tian

Psilocybin triggers an activity-dependent rewiring of large-scale cortical networks

This study shows psilocybin alters large-scale cortical network connectivity in mice by strengthening inputs from perceptual and medial regions and weakening cortico-cortical loops, dependent on drug-evoked spiking activity.

A Brain Reward Circuit Inhibited By Next-Generation Weight Loss Drugs

This paper shows small-molecule GLP1RAs modulate reward processing via a specific neural circuit in the central amygdala, affecting dopamine release and hedonic feeding.

Molecular and circuit determinants in the globus pallidus mediating control of cocaine-induced behavioral plasticity

This study identifies molecular and circuit mechanisms in the globus pallidus that regulate cocaine-induced behavioral plasticity, showing that GPePV cell activity predicts and modulates cocaine reward and sensitization.

Drug-induced changes in connectivity to midbrain dopamine cells revealed by rabies monosynaptic tracing

The paper uses rabies virus tracing to identify drug-induced changes in connectivity to midbrain dopamine cells and links these changes to gene expression patterns.

An extended amygdala-midbrain circuit controlling cocaine withdrawal-induced anxiety and reinstatement

This study identifies a midbrain dopamine projection to the amygdala that mediates cocaine withdrawal-induced anxiety and reinstatement of drug-seeking behavior.

Overnight caloric restriction prior to cardiac arrest and resuscitation leads to improved survival and neurological outcome in a rodent model

The paper shows that overnight caloric restriction before cardiac arrest and resuscitation improves survival and neurological outcomes in rodents, independent of SIRT-1 and BDNF.