Fluid Dynamics and Mixing

Inoculum-to-interface distance tunes productivity in static liquid cultures of wood-decay fungi

This study identifies the distance between fungal biomass and the liquid-air interface as a key factor in pellicle formation in static liquid cultures, showing that reducing this distance accelerates and stabilizes formation.

Tube-in-tube oxygen saturator enabling precise and dynamic control of liquid-phase oxygen concentrations for human cell culture applications

This paper introduces a tube-in-tube oxygen saturator for precise liquid-phase oxygen control in human cell culture, showing its performance and modeling capabilities.

Improved recombinant protein production and scale-up fermentation of Aspergillus oryzae hyphal-dispersion hydrophobin-deficient strain

This study develops a hyphal-dispersion mutant of Aspergillus oryzae with reduced hyphal adhesion and improved enzyme production and bioreactor performance.

CFD-based Bayesian Optimization of Stirring Strategies in Stirred Tank Cultures of Pluripotent Stem Cell Spheroids

This study optimizes stirring strategies for pluripotent stem cell spheroids using CFD and Bayesian optimization, improving suspension stability and reducing mechanical stress.

EFFICIENT EXPANSION OF NK-92 CELL LINE USING A NOVEL LOW-SHEAR STRESS BIOREACTOR

This paper describes a novel low-shear stress bioreactor for expanding NK-92 cells, showing improved cell growth and viability compared to traditional methods.

In Silico ModeIling of Shear Stress and Energy Dissipation Rate Effects on Human Pluripotent Stem Cell Proliferation in Vertical-Wheel Bioreactors

This study develops and validates a mathematical model to predict hPSC proliferation in vertical-wheel bioreactors by incorporating shear stress and energy dissipation rate effects, achieving accurate predictions with low error rates.

Low-cost DIY bioreactor system for educational and research applications: an accessible off-the-shelf bubble column concept

This paper introduces a low-cost DIY bioreactor system using standard fittings and sensors for microbial cultivation, offering an affordable alternative to commercial bioreactors.

Design and validation of a new flat-sheet membrane bioreactor system for bioprocessing research requiring very low gas fluxes

This paper introduces a new flat-sheet membrane bioreactor for controlled gas delivery at low fluxes, validated with oxygen and starch wastewater, showing stable performance over 320 days.

Modeling the biomechanics of cells on microcarriers in a stirred-tank bioreactor An ABM-CFD coupling approach

This paper develops a computational model combining agent-based modeling and computational fluid dynamics to study how rotor speed affects cell growth on microcarriers in bioreactors.