Topic · Ophthalmology · Medicine

Ocular Diseases and Behçet’s Syndrome

OpenAlex topic; a paper is listed when OpenAlex scores it at least 0.5 for this topic.

6 papers

Tissue resident memory T cells populate the human uveal tract

Andrew D. Foers, Ian R. Reekie, Lakshanie C. Wickramasinghe, Amy Ward, Thomas M. W. Buckley, Moustafa Attar, Soledad Aguilar-Munoa, Queen Pilapil, Maram E. A. Abdalla Elsayed, Sam Pledger, Ananya Bhalla, Robert Hedley, Sarah Hill, Dylan Windell, Keith Barton, , Colin J. Chu

The paper identifies resident memory T cells in the human uveal tract, showing their presence in both healthy and inflamed states and their potential role in uveitis.

Scientific Reports · Apr 3, 2026Peer-reviewedImmunology

A pathogenic CD4 T cell phenotype in experimental uveitis shares common features with other immune mediated inflammatory

Amy Ward, Oliver H. Bell, Luis Robles, Philippa J. P. Lait, Colin J. Chu, David A. Copland, Andrew D. Dick, Lindsay B. Nicholson

This study tracks pathogenic CD4 T cells in experimental uveitis and identifies shared features with other immune-mediated inflammatory conditions.

Discovery Immunology · Dec 2, 2025Peer-reviewedImmunology

IL-23 drives uveitis by acting on a novel population of tissue-resident entheseal T cells

Robert Hedley, Amy Ward, Colin J. Chu, Sarah E. Coupland, Serafim Kiriakidis, Peter Charles Taylor, Stephanie Georgina Dakin, Christopher Dominic Buckley, Jonathan P. Sherlock, Andrew D. Dick, David A. Copland

The paper identifies a novel population of IL-23 responsive T cells in the anterior uvea that drive uveitis and are present in humans.

JCI Insight · Aug 28, 2025Peer-reviewedImmunology

Exploring MicroRNA Signatures in Pediatric Non-infectious Uveitis: Meta-Analysis and Molecular Profiling of Patient Samples

Olga Wawrzyniak, Dariusz Wawrzyniak, Michał Smuszkiewicz, Paweł Głodowicz, Anna Gotz‐Więckowska, Katarzyna Rolle

The paper identifies miR-204-5p and miR-155-5p as potential molecular markers for autoimmune uveitis in children and shows shared molecular features with other autoimmune diseases.

Journal of Applied Genetics · Dec 18, 2024Peer-reviewedCell Biology

Effects of Primed Adipose Mesenchymal Stem Cell-Derived Exosomes on Immunomodulation in Behcet Uveitis

Merve Gözel, Ayse Dilara Aydemir, Hümeyra Nur Kaleli, Feray Cosar, Ümit Yaşar Güleser, Eda Kusan Unlu, Cem Kesim, Billur Sezgin, Afsun Şahin, Didar Uçar, Gülen Hatemi, Murat Hasanreisoğlu

This study examines the immunomodulatory effects of IFN-gamma primed adipose-derived mesenchymal stem cell exosomes on Behcet uveitis, showing increased apoptosis and cytokine shifts in T lymphocytes.

Acta Ophthalmologica · Jan 1, 2024Peer-reviewedImmunology

Functionally distinct ERAP1 and ERAP2 are a hallmark of HLA-A29-(Birdshot) Uveitis.

Jonas J. W. Kuiper, Jessica van Setten, Matthew A.M. Devall, Mircea Cretu-Stancu, Sanne Hiddingh, Roel A. Ophoff, Tom Missotten, Mirjam E. J. van Velthoven, Anneke I. den Hollander, Carel B. Hoyng, Edward James, Emma Reeves, Miguel Cordero‐Coma, Alejandro Fonollosa, Alfredo Adán, , Timothy R. D. J. Radstake

This study identifies functionally distinct ERAP1 and ERAP2 haplotypes associated with Birdshot Uveitis and shows their combined effect enhances disease risk.

Human Molecular Genetics · Sep 10, 2018Peer-reviewedGenetics