Christopher Dominic Buckley

LIF is a pro-algesic mediator in human and mouse models of arthritis-related pain

This study identifies LIF as a key pro-algesic cytokine in arthritis-related pain, showing its role in neuronal signalling and pain-like behaviours in human and mouse models.

Tissue resident memory T cells populate the human uveal tract

The paper identifies resident memory T cells in the human uveal tract, showing their presence in both healthy and inflamed states and their potential role in uveitis.

The ontogeny of myeloid-stromal synovial tissue niches in rheumatoid arthritis.

This study shows human synovial tissue-resident macrophages develop from monocytes guided by fibroblast-derived cues in specific spatial niches, using a novel organoid system.

IL-23 drives uveitis by acting on a novel population of tissue-resident entheseal T cells

The paper identifies a novel population of IL-23 responsive T cells in the anterior uvea that drive uveitis and are present in humans.

An end-to-end framework for Cell DIVE multiplexed imaging and spatial immune microenvironment analysis

CD4+ tissue-resident memory Th17 cells are a major source of IL-17A in Spondyloarthritis synovium tissue

This study identifies CD4+ tissue-resident memory Th17 (TRM17) cells as the main source of IL-17A in SpA synovium, showing their role in disease pathology and potential as therapeutic targets.

Wnt signaling drives stromal inflammation in inflammatory arthritis

This study shows Wnt signaling drives inflammation in fibroblasts of inflammatory arthritis, suggesting it as a therapeutic target.

Spatial programming of fibroblasts promotes resolution of tissue inflammation through immune cell exclusion

The paper uses multi-omic spatial analysis to identify fibroblast subsets in inflamed synovium that create tissue niches influencing immune cell trafficking and inflammation resolution.

A multiomic atlas of human early skeletal development

This study constructs a multiomic atlas of human early skeletal development using single-nuclei transcriptomics, epigenomics, and spatial transcriptomics to uncover regulatory mechanisms and cell states involved in bone and joint formation.

Cross-tissue, single-cell stromal atlas identifies shared pathological fibroblast phenotypes in four chronic inflammatory diseases