Ocular Diseases and Behçet’s Syndrome

Inflammatory arthritis disrupts ocular immune privilege by compromising blood-retinal barrier integrity and promoting uveitogenic T cell recruitment

This study shows inflammatory arthritis disrupts the blood-retinal barrier and promotes T cell recruitment to the eye, increasing susceptibility to uveitis without causing overt ocular disease.

Distinct Programs of Tissue Adaptation Shape Vitreous CD4+ and CD8+ T-cell States in Chronic Uveitis

The paper compares CD4+ and CD8+ T-cell states in vitreous and peripheral blood from chronic uveitis patients, finding distinct tissue-adaptive programs in the vitreous.

Macrophage immunosenescence prolongs intraocular inflammation in aged mice via impaired induction of regulatory T cells

This study shows that aging impairs macrophage-induced regulatory T cells in mice, leading to chronic uveitis by linking immunosenescence to persistent inflammation.

Laquinimod treatment attenuates EAU by inhibiting both the inductive and effector phases in an APC-dependent manner

This study shows Laquinimod reduces EAU by targeting AhR-expressing antigen-presenting cells, inhibiting T cell activation and promoting regulatory T cells.

Vitamin A is necessary for acquisition, but not for expression or progression, of CNS autoimmunity

This study shows that vitamin A is needed for initial T cell activation in autoimmune diseases but not for maintaining or expressing effector functions once acquired.

AI-Driven Analysis Unveils Functional Dynamics of Müller Cells in Retinal Autoimmune Inflammation

The paper reanalyzes a scRNA-seq dataset to identify Muller cell subgroups and their functional dynamics in retinal inflammation, revealing their role in modulating Th1 cell activity.

Using Hierarchical Similarity To Examine The Genetics of Behcet's disease

This study uses hierarchical similarity to identify genetic factors of Behcet's disease and related autoimmune diseases with genetic overlap.

Unilateral relapse of Behcet’s disease-associated uveitis does not appear to cause asymmetric tear protein profiles

The paper investigates whether unilateral relapse of Behcet’s disease uveitis causes asymmetric tear protein profiles, finding no significant differences.

An Amino Acid Motif In HLA-DRB1 Distinguishes Patients With Uveitis In Juvenile Idiopathic Arthritis

The paper identifies serine-11 in HLA-DRB1 as a risk factor for uveitis in JIA, showing sex-specific association and peptide-binding preferences.