Author

Przemysław Grygier

Jagiellonian UniversityORCID 0000-0003-2022-0396Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1 Organism:virus· 1

Frequent Co-Authors

Anna CzarnaiD· 3 shared Grzegorz M. PopowicziD· 2 shared Adrien DelpaliD· 1 shared Alex MatsudaiD· 1 shared Angélique Sanchez DafuniD· 1 shared Ayse Seda YazgiliiD· 1 shared Colin Robinson· 1 shared Craig D. L. SmithiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersBiochemistry

Anna CzarnaORCID

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3 papers

Recent·Most cited

BiochemistryRSC Medicinal ChemistryPeer-reviewedJan 1, 2026

Crystallographic characterisation and development of bi-substrate inhibitors of coronavirus nsp14 methyltransferase

Irene Georgiou, Colin Robinson, Sean N. O’Byrne…·Ian Hugh Gilbert

The paper develops bi-substrate inhibitors of SARS-CoV-2 nsp14 methyltransferase using structure-guided design, achieving nanomolar potency but limited cellular antiviral activity.

2 citations

virusexperimental assay

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BiochemistrybioRxivPreprintMar 18, 2025

Revealing the unexpected interplay between the Proteasome Activator PA200 and the immunoproteasome

Dušan Živković, Fatme Mourtada, Angélique Sanchez Dafun…·Marie‐Pierre Bousquet

This paper reveals structural and functional differences in PA200 interaction with the immunoproteasome (i20S) compared to the standard proteasome (s20S), showing PA200 enhances i20S activation and regulates its gene expression.

2 citations

structural biologyexperimental assay

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Molecular BiologybioRxivPreprintJun 10, 2024

Curcumin Inhibition of DYRK Kinases

Filipe Menezes, Przemysław Grygier, Katarzyna Pustelny…·Anna Czarna

This paper investigates how curcumin interacts with DYRK1A and DYRK2 kinases, showing its potential to treat diabetes and cancer by modulating these proteins.

DOI 10.1101/2024.06.10.598318

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