Discovering and designing multistate protein assemblies
Chelsea N. Fries, Samuel W. K. Tipps, Adam J. Wargacki, Judith Ahr, Rebecca Skotheim, Connor Weidle, Justin A. Decarreau, Yang Hsia, Andrew J. Borst, Neil P. King
This paper designs protein assemblies that switch between structural states using engineered interfaces, demonstrating temperature-responsive transitions from capsids to 2D arrays.
bioRxiv · Oct 28, 2026 · PreprintBiochemistry