Justin A. Decarreau

This paper designs protein assemblies that switch between structural states using engineered interfaces, demonstrating temperature-responsive transitions from capsids to 2D arrays.

This study designs de novo cysteine proteases with high activity and structural novelty, achieving 19% success rate and up to 3 x 10^7 rate enhancement over background reactions.

This paper presents a modular strategy to design programmable, highly porous protein crystals with tunable architectures and composition, enabling applications in catalysis and biomedicine.

The paper designs and characterizes a random protein walker that diffuses along a designed protein track, finding that walkers with more feet move faster.

This study shows that Kif9 regulates centriolar satellite positioning and mitotic progression by affecting centrosome maturation and proteostasis.

The paper designs orthogonal fluorophore-binding proteins using deep learning for multiplex imaging, demonstrating high specificity and utility in labeling and monitoring subcellular processes.

This paper presents a computational strategy to design bifaceted protein nanomaterials with two distinct sides, enabling anisotropic functionalization and controlled structural variation.

The paper develops RFdiffusion to generate protein binders for IDPs/IDRs, achieving nanomolar affinity and functional applications in amylin and IL2RG.

This paper computationally designs multi-component protein filaments that assemble into ordered fibers, validated by cryoEM, and shows regulation via phosphorylation.

The paper designs peptide traps that bind amyloidogenic segments in {beta}-strand and {beta}-hairpin conformations, effectively blocking fibril assembly for A{beta}42.

This paper designs reconfigurable asymmetric protein assemblies using implicit negative design principles, enabling stable subunit exchange and diverse complex formations.

The paper designs binary 2D protein co-assemblies that form ordered, biologically active materials with potential therapeutic applications.