Chromatin Remodeling and Transcriptional Silencing Define the Dynamic Innate Immune Response of Tissue Resident Macrophages After Burn Injury.
Han Sang Kim, Marie‐Pierre L. Gauthier, Aidan Higgs, Denise A. Hernandez, Mingqi Zhou, Jason Orr Brant, Rhonda L. Bacher, Dijoia B. Darden, Shannon Margaret Wallet, Clayton E. Mathews, Lyle L. Moldawer, Philip Alexander Efron, Michael P. Kladde, Robert Maile
This study identifies a biphasic epigenetic and transcriptional response in macrophages after burn injury, revealing locus-specific chromatin remodeling and immune dysfunction.
Shock · Oct 22, 2025Peer-reviewedImmunology