Lyle L. Moldawer

Divergent chromatin remodeling in post-sepsis MDSCs underlies MHC class II repression in CCI

The paper profiles chromatin accessibility in post-sepsis MDSCs, showing divergent epigenetic trajectories between rapid recovery and chronic critical illness, with MHC class II repression in CCI.

Prolonged Loss of Oxidative Phosphorylation and Mitochondrial Mass Characterize CD66b+ Leukocytes from Patients with Sepsis

This study identifies prolonged reduced oxidative metabolism and mitochondrial mass in CD66b+ leukocytes from sepsis patients, linked to adverse outcomes and gene silencing.

Chromatin Remodeling and Transcriptional Silencing Define the Dynamic Innate Immune Response of Tissue Resident Macrophages After Burn Injury.

This study identifies a biphasic epigenetic and transcriptional response in macrophages after burn injury, revealing locus-specific chromatin remodeling and immune dysfunction.

Age- and Sex- Driven Transcriptional and Metabolic Diversity in Myeloid-Derived Suppressor Cells After Mouse Sepsis

This study examines age and sex effects on MDSCs in sepsis using single-cell RNA sequencing, finding differences in expansion, transcriptome, and metabolism.

International multi-cohort analysis identifies novel framework for quantifying immune dysregulation in critical illness: results of the SUBSPACE consortium

The paper identifies a novel framework to quantify immune dysregulation in critical illness by analyzing transcriptomic data across multiple cohorts.

Sepsis Induces Age- and Sex-Specific Chromatin Remodeling in Myeloid-derived Suppressor Cells

This study maps epigenetic changes in MDSCs after sepsis, revealing age- and sex-specific chromatin remodeling linked to immune dysfunction.

Determining potential immunomodulatory drug efficacy in sepsis using ELISpot

This study uses ELISpot to assess immunomodulatory drug effects on cytokine production in sepsis patients and healthy controls.

Resolvin D2/GPR18 signaling enhances monocytic myeloid-derived suppressor cell function to mitigate abdominal aortic aneurysm formation

This study shows RvD2/GPR18 signaling enhances M-MDSC function to reduce AAA formation by suppressing inflammation and vascular remodeling.

Mortality prediction in sepsis via gene expression analysis: a community approach

The paper develops gene-expression-based prognostic models for 30-day mortality in sepsis using community-onset and hospital-acquired sepsis cohorts, showing improved prediction when combined with clinical scores.