Michael P. Kladde

The paper profiles chromatin accessibility in post-sepsis MDSCs, showing divergent epigenetic trajectories between rapid recovery and chronic critical illness, with MHC class II repression in CCI.

This study identifies prolonged reduced oxidative metabolism and mitochondrial mass in CD66b+ leukocytes from sepsis patients, linked to adverse outcomes and gene silencing.

This study identifies a biphasic epigenetic and transcriptional response in macrophages after burn injury, revealing locus-specific chromatin remodeling and immune dysfunction.

This study examines age and sex effects on MDSCs in sepsis using single-cell RNA sequencing, finding differences in expansion, transcriptome, and metabolism.

This study maps epigenetic changes in MDSCs after sepsis, revealing age- and sex-specific chromatin remodeling linked to immune dysfunction.

This study uses multi-omics profiling to show that low-dose ionizing radiation in Arabidopsis triggers genetic and epigenetic responses mediated by the ethylene signaling pathway.

The paper introduces methylscaper, an R/Shiny app for visualizing DNA methylation and nucleosome occupancy in single-molecule and single-cell data, showing its ability to identify biologically relevant chromatin features.