Jason Orr Brant

This study shows that clearing senescent cells with 753b improves bone marrow aging by restoring HSC function and niche balance.

The paper profiles chromatin accessibility in post-sepsis MDSCs, showing divergent epigenetic trajectories between rapid recovery and chronic critical illness, with MHC class II repression in CCI.

This study identifies a biphasic epigenetic and transcriptional response in macrophages after burn injury, revealing locus-specific chromatin remodeling and immune dysfunction.

This study maps epigenetic changes in MDSCs after sepsis, revealing age- and sex-specific chromatin remodeling linked to immune dysfunction.

This study compares molecular and histologic outcomes of spinal cord injury in spiny mice (Acomys cahirinus) and C57BL/6 mice, finding reduced inflammation and fibrosis in Acomys.