Nicotinic Acetylcholine Receptors Study

Imaging FDG PET/CT Study of Nicotinic Acetylcholinergic Receptor α2 Knock-Out Mice and α2 Hypersensitive Mice Compared to Control Mice: Male-Female Differences and Nicotine Effects

This study uses FDG PET/CT to compare glucose metabolism in mice with different nicotinic acetylcholinergic receptor α2 genotypes, finding sex differences and nicotine effects on brain and IBAT uptake.

Diurnal Variations in the Cholinergic System of the Nucleus Accumbens

This study investigates diurnal variations in cholinergic interneuron activity and nicotinic signaling in the nucleus accumbens using electrophysiological recordings in rodents.

6-Methylnicotine is a strong agonist at α4β2 and α3β4 nicotinic cholinergic receptors

This study compares 6-Methylnicotine and nicotine's effects on α4β2 and α3β4 nicotinic cholinergic receptors, finding 6-MN is more potent and upregulates these receptors.

Nicotinic control of dopamine release shapes striatal output and engages adaptive action selection.

This study shows that nicotinic acetylcholine receptors in midbrain neurons control dopamine release in the striatum, affecting reward learning and action selection in mice.

Nicotinic modulation of frontal circuits breaks the cycle of attentional performance failure

The paper identifies a cholinergic mechanism in frontal circuits that restores attentional performance after repeated errors in a mouse model.

A human CHRNA6 3' UTR variant alters the molecular environment and microRNA engagement of the adolescent VTA without changing Chrna6 transcript abundance

This study identifies a non-coding variant in CHRNA6 that affects miRNA engagement and transcriptional networks in the adolescent VTA without altering transcript abundance.