Protein Interaction Studies and Fluorescence Analysis

Structural conservation and expanded functionality of hyper-stable human serum albumin variants

This study validates engineered hyper-stable human serum albumin variants for their structural integrity and functional adaptability in biotechnological applications.

Investigating Quinclorac Binding to Human Serum Albumin using Spectroscopy and Molecular Docking

This study investigates quinclorac binding to human serum albumin using spectroscopy and molecular docking, revealing high-affinity binding and identifying Sudlow site I as the primary binding site.

Structural Categorization and identification of electrostatic interactions in two proposed Human Serum Albumin dimerization patterns and dipyridamole interaction.

This study presents high-resolution crystal structures of two HSA dimerization patterns and analyzes electrostatic interactions and dipyridamole binding, showing their potential for drug delivery applications.

Observing picomolar protein unfolding using resonance light scattering

The paper introduces a label-free method to determine protein melting points at ultralow concentrations, demonstrating its application to botulinum toxin A stabilized by human serum albumin.

Plasma Protein Binding as an Optimizable Parameter for In Vivo Efficacy

This study challenges the exclusion of plasma protein binding from drug design optimization by showing it can enhance efficacy and safety through clearance-dependent strategies.

Structural and evolutionary analysis unveil functional adaptations in the promiscuous behavior of serum albumins

The paper identifies a conserved promiscuous reaction in serum albumins across mammals and suggests evolutionary adaptations in residues with unknown functions.