Coagulation, Bradykinin, Polyphosphates, and Angioedema

Cryo-EM structures of apo human Factor XIa reveal catalytic-domain flexibility and exposure of the Factor IX-binding site

This study uses cryo-EM to show that Factor XIa exists as a dynamic ensemble with flexible catalytic domains that expose the Factor IX-binding site.

Common variants near the bradykinin receptor B2 gene are associated with angioedema induced by angiotensin-converting-enzyme inhibitor treatment - a genome wide association study

This GWAS identifies common variants near BDKRB2 associated with angioedema from ACEi treatment, showing genetic risk and blood pressure effects.