Christos Gatsogiannis

Cryo-EM structures of apo human Factor XIa reveal catalytic-domain flexibility and exposure of the Factor IX-binding site

This study uses cryo-EM to show that Factor XIa exists as a dynamic ensemble with flexible catalytic domains that expose the Factor IX-binding site.

A nested shell structure coordinates enzyme communication in pyruvate oxidation

This paper proposes a multi-scale model of the pyruvate dehydrogenase complex (PDHc) revealing a nested shell structure that coordinates enzyme communication during pyruvate oxidation.

Structural basis of apoptosis induction by the mitochondrial voltage dependent anion channel

This study reveals how VDAC1 oligomerization triggers apoptosis by exposing its N-terminal helix, which neutralizes anti-apoptotic BclxL and promotes pore formation by Bak.

PEX39 facilitates the peroxisomal import of PTS2 proteins

This study identifies PEX39 as a cytosolic peroxin that facilitates PTS2-protein import by interacting with PEX7 and stabilizing its binding to cargo.

Structure and mechanism of the RalGAP tumor suppressor complex

This study presents the cryo-EM structure of the RalGAP tumor suppressor complex, revealing its tetrameric architecture and providing insights into its function and relevance in cancer.

From dimer to tetramer: the evolutionary trajectory of C4 photosynthetic-NADP-ME oligomeric state in Poaceae

This study investigates how amino acid changes in C4-NADP-ME and nonC4-NADP-ME enzymes affect their oligomeric states and function in Poaceae species.

High-resolution structures of the UapA purine transporter reveal unprecedented aspects of the elevator-type transport mechanism.

The paper reports cryo-EM structures of UapA, revealing the role of water, lipids, and the N-tail in its transport mechanism and subcellular trafficking.

TUBB4B variants specifically impact ciliary function, causing a ciliopathic spectrum

The paper identifies TUBB4B mutations causing distinct ciliopathic diseases by affecting microtubule dynamics and cilia formation in humans and mice.

Structure of the peroxisomal Pex1/Pex6 ATPase complex bound to a substrate

The paper reports cryoEM structures of the Pex1/Pex6 ATPase complex from yeast, revealing how it translocates substrates through conformational changes and mechanical force propagation.

Asymmetric horseshoe-like assembly of peroxisomal Yeast Oxalyl-CoA synthetase

The paper determines the structural assembly of yeast Oxalyl-CoA synthetase, revealing asymmetric hexameric arrangements and identifying key self-association interfaces.

Towards the molecular architecture of the peroxisomal receptor docking complex

The paper provides the first structural characterization of the yeast peroxisomal docking complex Pex14p/Pex17p, revealing its subunit organization and potential role in import pore formation.

Cryo-EM structure of the fully-loaded asymmetric anthrax lethal toxin in its heptameric pre-pore state

The paper reports cryo-EM structures of anthrax lethal toxin in its heptameric pre-pore state, revealing LF binding dynamics and conformational changes.

Structure of the human BBSome core complex in the open conformation

The paper presents a high-resolution cryo-EM structure of a human BBSome core subcomplex, revealing its open conformation and interactions with cargo and membrane components.

Conserved architecture of Tc toxins from human and insect pathogenic bacteria

The paper presents high-resolution structures of five TcA toxins from different bacteria, revealing conserved architecture and a common mechanism of action despite previous suggestions of variability.

Cryo-EM structure of the ClpXP protein degradation machinery

This paper presents the first high-resolution cryo-EM structure of ClpXP from Listeria monocytogenes, revealing the binding interface and activation mechanism of the complex.