Electroconvulsive Therapy Studies

Accurate Hippocampal Electric Field Modeling for Electroconvulsive Therapy: Numerical Accuracy and Convergence

The paper evaluates numerical accuracy and convergence of hippocampal electric field modeling across three methods in ECT patients, finding significant discrepancies at low resolutions.

Model-based assessment of race, sex, and electrode montage in ECT

This study assesses how race, sex, and electrode montage affect brain-wide current flow during ECT using computational models.

Electroconvulsive stimulation drives cortical spreading depression dependent immediate early gene expression in mice

This study shows that electroconvulsive stimulation (ECS) in mice triggers cortical spreading depression (CSD), which increases Fos expression and is linked to positive ECT outcomes.

Electroconvulsive seizures for alcohol use disorder: a preclinical study

This study evaluates electroconvulsive seizures (ECS) as a treatment for alcohol use disorder in a preclinical model, showing reduced ethanol consumption and potential involvement of BDNF.

Gut Microbiota-derived Adenosine Determines the Efficacy of Electroconvulsive Therapy for Depression

This study shows that gut microbiota-derived adenosine affects the effectiveness of electroconvulsive therapy (ECT) in depression by modulating neural activity and synaptic plasticity.

Seizure-induced Transient Disruptive Changes in Brain Microstructure

This study shows that a single ECT session causes transient, reversible brain microstructural changes resembling vasogenic edema, which may precede neuroplasticity and therapeutic effects.

A Clinically Aligned Murine Model of Electroconvulsive Stimulation Reverses Social Aversion and Displays Fear Memory Impairment After Chronic Social Defeat Stress

This study develops a clinically relevant murine model of electroconvulsive stimulation to investigate its effects on social behavior and gene expression after chronic social defeat stress.

Electroconvulsive stimuli reverse neuro-inflammation and behavioral deficits in a mouse model of depression.

The paper shows electroconvulsive stimuli reverse neuro-inflammation and behavioral deficits in a mouse depression model by identifying molecular pathways and genes involved in recovery.

Factors Affecting Electroconvulsive Therapy Ictal Outcomes: Duration and Postictal Suppression

This study identifies factors affecting ECT ictal outcomes by analyzing stimulus metrics, EEG parameters, and patient data using regression models.