Torsten Klengel

This study develops a clinically relevant murine model of electroconvulsive stimulation to investigate its effects on social behavior and gene expression after chronic social defeat stress.

This study identifies specific types and ages of childhood maltreatment associated with accelerated brain aging in adulthood.

This paper develops two epigenetic clocks for rhesus macaques and finds that early life adversity, specifically infant maltreatment, is associated with epigenetic age acceleration.

This study uses spatial transcriptomics to show gene expression changes across brain regions in mice after auditory threat conditioning, revealing altered transcriptional connectivity involving steroidogenic factor 1.

This study shows that SKA2-regulated hyperactive secretory autophagy contributes to neuroinflammation and neurodegeneration in Alzheimer's disease.

The paper uses natural language processing on post-mortem electronic health records to derive RDoC cognitive scores and associates them with Alzheimer's disease neuropathology.

This study identifies Ptgs2 as a stress-induced gene in specific prefrontal cortical neurons that mediates anxiety-like behaviors in mice.

The paper identifies CS6 clusters as extracellular matrix microenvironments that support coordinated multi-dendrite synaptic plasticity in response to sensory stimuli.

This study identifies similar transcriptional responses to acute and chronic alcohol drinking in mouse amygdala subnuclei, highlighting shared pathways and potential therapeutic targets for AUD.

The paper identifies an epigenetic signature in rhesus macaques linked to innate fear responses and shows its association with human acoustic startle responses.

This study shows that childhood maltreatment in rhesus monkeys leads to molecular and behavioral changes in offspring across generations without behavioral transmission.

The paper identifies mir-135b-5p as a regulator of persistent stress-enhanced memory and a potential therapeutic target and biomarker for PTSD.

The paper identifies SNRNP35 as a trauma type-specific PTSD gene through analysis of genetically regulated gene expression in PTSD cases and controls.

This study identifies 40 CpG sites with differential methylation at age 7 linked to adversity exposure timing, showing infancy as a sensitive period for DNAm changes.

This study conducts the largest GWAS for PTSD, identifying 6 genome-wide significant loci in European and African ancestries and highlighting novel biological pathways.