Cholinesterase and Neurodegenerative Diseases

Tunable nucleofugality in carbamoyl-bearing covalent cholinesterase inhibitors

This study explores carbamoyl warhead reactivity in covalent cholinesterase inhibitors, identifying structure-reactivity relationships and demonstrating a highly selective, irreversible inhibitor.

Pharmacological Reversal of Attention Deficits in Non-Human Primates: Implications for Alzheimer's Disease

This study evaluates attention-enhancing drugs in non-human primates using a pharmacological model of cholinergic dysfunction, finding nicotine effectively restores attentional performance.

2D-QSAR and Molecular Docking based virtual screening of the herbal molecules against Alzheimers Disorder: An approach to predict CNS activity

The paper develops a 2D-QSAR model to predict AChE inhibitory activity and BBB penetration of herbal molecules for Alzheimer's treatment, identifying amentoflavone as the most promising candidate.

AchE-OGT dual inhibitors: Potential Partners in Handling Alzheimer’s Disease

The paper identifies donepezil as a dual inhibitor of AchE and OGT, revealing structural features that enable interactions with both targets.