Cholinesterase and Neurodegenerative Diseases

Cardiac acetylcholinesterase and butyrylcholinesterase have distinct localization and function

This study investigates the localization and function of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) in the heart, revealing distinct roles and responses to inhibitors.

Development of a High-throughput Assay to Identify Novel Reactivators of Acetylcholinesterase

The paper develops a high-throughput assay to test compounds for reactivating acetylcholinesterase inhibited by organophosphates, validated with 42 in silico selected compounds.

Morphing Cholinesterase Inhibitor Amiridine into Multipotent Drugs for the Treatment of Alzheimer's Disease

This study develops multi-target directed ligands (MTDLs) by modifying amiridine, a cholinesterase inhibitor, to enhance its therapeutic potential for Alzheimer's disease.

Neuroprotective derivatives of tacrine that target NMDA receptor and acetyl cholinesterase - Design, synthesis and biological evaluation

The paper designs, synthesizes, and evaluates neuroprotective derivatives of tacrine that target both acetylcholinesterase and NMDA receptors, showing reduced hepatotoxicity and potential therapeutic benefits.

Rescuing the attentional performance of rats with cholinergic losses by the M1 positive allosteric modulator TAK-071

This study shows that TAK-071, an M1 PAM, improves attentional performance in rats with cholinergic losses, particularly in recovery after distractors.

TAK-071, a muscarinic M1 receptor positive allosteric modulator, attenuates scopolamine-induced quantitative electroencephalogram power spectral changes in cynomolgus monkeys

This study evaluates TAK-071's effect on qEEG power bands in cynomolgus monkeys challenged with scopolamine, showing suppression of scopolamine-induced increases in alpha, theta, and delta power bands.