Ashwin Jainarayanan

This study shows that sustained antigenic engagement leads to multidimensional remodeling and functional diversification of CTLs, maintaining cytotoxic activity while creating functionally distinct states.

The paper shows that TCR and IL2 receptor signaling synergize at the immunological synapse of CD8+ T cells, enhancing T-T synapse formation and function.

This study shows that chemotherapy, specifically CarboTaxol, synergizes with cancer vaccines and anti-PD-1 to improve tumor control and survival by expanding stem-like TCF1+CD8+ T cells.

This paper develops a method to isolate and characterize SMAPs from NK-92 cells, showing their cytotoxic activity against tumor cells in vitro and in vivo.

This study shows IGF-1 suppresses immune-related pathways in prostate cancer cells, reducing antigen presentation and increasing PD-L1, which may explain poor immunotherapy response.

The paper identifies ThrEDs, a novel type of extracellular particle that accelerates wound healing and reduces fibrotic responses in patient-derived myofibroblasts.

This study identifies a JAK-independent mechanism of STAT3 activation in RA through TCR-dependent phosphorylation at the immunological synapse, suggesting a new therapeutic target.

This study characterizes extracellular vesicles from activated CD4 T cells and shows their pro-inflammatory effects on antigen-presenting cells, providing a resource for EV-based therapeutic development.

This study shows perforin triggers pyroptosis in target cells by activating the NLRP3/caspase-1/gasdermin D pathway, while sustained CTL interaction leads to apoptosis.

The paper develops a theoretical model to predict promoter strength in Saccharomyces cerevisiae based on nucleotide sequence and provides an online tool for quantifying promoter strength.

This study identifies potential NMDA receptor antagonists through pharmacophore modeling and virtual screening, validated by in-vivo testing in mice.

The paper uses in silico methods to analyze the structural and functional impact of SNPs in the Pleckstrin gene, identifying two SNPs that alter its structure and function.

The paper identifies 423 population-invariant genes across 60,706 human genomes, finding many are X-linked, non-expressed, and associated with disease.

The paper analyzes how intronic miRNAs regulate gene expression in specific cellular contexts and shows their role in controlling protein crowding through translation regulation.

The paper integrates centenarian genomes and spatio-temporal expression profiles to identify potential drug targets for schizophrenia, suggesting repurposed therapies for neuropsychiatric disorders.

The paper identifies two novel NMDA receptor antagonists using pharmacophore modeling, virtual screening, and molecular docking.

The paper identifies donepezil as a dual inhibitor of AchE and OGT, revealing structural features that enable interactions with both targets.