Casey R. Vanderlip

Behavioral and Pharmacological Validation of the Differential Reinforcement of Low-Rate Behavior Paradigm in Non-Human Primates

This study validates the Differential Reinforcement of Low-Rate Behavior (DRL) task in non-human primates as a tool for assessing antidepressant efficacy and side effects.

A Scalable Touchscreen-Based Spatial Working Memory Task for Cross-Species Research

This paper introduces a touchscreen-based spatial working memory task for marmosets and humans, showing that accuracy declines with longer delays and smaller spatial separations, and that these factors interact.

Myo-inositol and total NAA in the hippocampus are linked to CSF tau pathology in cognitively normal older adults

The paper links hippocampal myo-inositol and total NAA levels to CSF tau pathology in cognitively normal older adults using 1H-MRS.

Pharmacological Reversal of Attention Deficits in Non-Human Primates: Implications for Alzheimer's Disease

This study evaluates attention-enhancing drugs in non-human primates using a pharmacological model of cholinergic dysfunction, finding nicotine effectively restores attentional performance.

Cognitive strategy accounts for failure on a hippocampal relational memory task in non-human primates

This study shows non-human primates use a habit-based strategy rather than relational memory in a TP task, with no age-related decline in performance.

Parallel patterns of cognitive aging in marmosets and macaques

This study compares age-related working memory deficits in macaques and marmosets, finding similar patterns that support marmosets as a valid model for cognitive aging research.

Lower GABA levels in the posterior cingulate are linked with poorer episodic memory in healthy older adults

Amyloid-β deposition in basal frontotemporal cortex is associated with selective disruption of temporal mnemonic discrimination

The paper investigates how amyloid-beta accumulation in specific brain regions relates to memory deficits in preclinical Alzheimer's disease, finding a selective impact on temporal memory.

APOE4 Increases Susceptibility to Amyloid, Accelerating Episodic Memory Decline

This study shows APOE4 carriers experience faster episodic memory decline linked to amyloid duration, with a dose-dependent effect in homozygotes, but not other cognitive domains.

Digital cognitive assessments as low-burden markers for predicting future cognitive decline and tau accumulation across the Alzheimer's spectrum

This study evaluates digital cognitive assessments as low-burden tools for predicting cognitive decline and tau accumulation in Alzheimer's disease, finding they outperform Aβ and tau PET in detecting mild cognitive impairment and predicting decline.

Cognitive modeling of the Mnemonic Similarity Task as a digital biomarker for Alzheimer's Disease

This study uses cognitive modeling of the Mnemonic Similarity Task to detect early signs of Alzheimer's Disease before cognitive decline, showing better prediction of biomarkers than traditional metrics.

The Common Marmoset as a Translational Model for Longitudinal Studies of Cognitive Aging and Individual Vulnerability to Decline

The paper develops a cognitive test battery for marmosets to study aging and cognitive decline, finding significant individual variability and domain-specific decline similar to humans.

Domain-specific cognitive impairment reflects prefrontal dysfunction in aged common marmosets

This study shows aged common marmosets exhibit domain-specific cognitive impairments linked to prefrontal cortex dysfunction, similar to humans.

Violation of the ultrastructural size principle in the dorsolateral prefrontal cortex underlies working memory impairment in the aged common marmoset (Callithrix jacchus)

This study identifies age-related synapse loss and violation of the ultrastructural size principle in the marmoset dlPFC as factors underlying working memory impairment in aged individuals.

Age-related learning and working memory impairment in the common marmoset

This study evaluates the common marmoset as a model of age-related cognitive impairment by analyzing working memory changes across its lifespan.